About Physician Therapeutics

The History of Physician Therapeutics

Physician Therapeutics is a division of Targeted Medical Pharma Inc. Physician Therapeutics was founded as a Nevada limited liability company on June 26, 2003. It distributes proprietary Medical Foods and Convenience Packed Pharmaceutical products to dispensing physicians in the United States.

The early development of the Company’s products began in the cardiovascular testing laboratory. Certain patterns of autonomic nervous system derangement were observed on long-term electrocardiographic (EKG) recordings. These abnormal patterns corresponded to specific disease states and were associated with conditions known to have increased nutritional requirements specific to certain diseases. Over a period of five years, Company scientists assembled an extensive database of peer reviewed medical and scientific journal articles that confirmed that the common threads linking certain disease states were a variety of neurotransmitter deficiencies and imbalances. The challenge was then to identify the anatomical cause of neurotransmitter depletion and to develop interventions that would encourage the body to restore healthy neurotransmitter levels that would improve the symptoms of disease.

In 1998, the Company scientists joined a group of investigators from the University of Texas, Southwestern Medical Center to attempt to determine the underlying causes of Gulf War Syndrome, a condition characterized by neurotransmitter depletion. After many years of testing and analysis, the results of this study revealed that lesions in key areas of the brain were associated with the disease process. This work was published in November 2004 in the American Journal of Medicine.

Sentra AM and Sentra PM were the first products developed to address the needs of patients suffering from the effects of chemical exposures. Using the benchmark of Heart Rate Variability analysis to measure autonomic nervous system response to therapeutic interventions, the five-step process that became Targeted Cellular Technology was developed.

On April 10, 2003 Physician Therapeutics entered into a Licensing Agreement for the Sales and Marketing Rights for six proprietary TCT medicinal nutrient products with J Network, Inc ("JNT"). The exclusive agreement was signed and provides for Physician Therapeutics, a subsidiary of Targeted Medical Pharma, to manufacture and JNT to distribute on a mass distribution brands known as Lister V, Sentra AM, Sentra PM, AppTrim, and Nutra Smokeless, in Japan.

In 2006, Physician Therapeutics introduced the first six convenience packed products featuring proprietary Medical Foods packaged for convenience with generic pharmaceuticals normally prescribed for specific disease states. The products include therapies for hypertension, pain syndromes, sleep disorders, metabolic syndrome, diabetes mellitus, and viral infection.

In 2007, the company completed its first double-blind placebo-controlled trials of medical foods along with co-administered generic pharmaceuticals. These studies demonstrated the efficacy of medical foods administered alone to manage the nutrient requirements of the disease. In addition, the use of medical foods to manage the nutrient requirements resulted in a reduction of the effective dose of the generic pharmaceutical and reduced side effects. Physician Therapeutics' proprietary line of Medical Foods, are exclusive to the current Medical Foods marketplace having the unique ability to produce pharmacological effects and treat symptoms of diseases.